Figure 4
Effect of AP-2α over expression on gemcitabine sensitivity of pancreatic cancer cells. (A) In vitro growth-inhibitory effect of gemcitabine against the mock CAPAN-1 cells (C5) and the four clones that stably overexpressed AP-2α transcription factor. Cell growth was assessed by cell counting of surviving cells. For each cell line, results are expressed as the percentage of surviving cells relative to the untreated cells that were arbitrarily given a 100% value. Results are shown as mean of two independent experiments run in triplicate. *, P<0.05. (B) Cell cycle distribution profiles of C5 control cells, α27 and α42 treated with 0.1 μg ml–1 of gemcitabine for 24 h. The values are expressed as the mean of three independent experiments.
