Figure 3 | British Journal of Cancer

Figure 3

From: Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death

Figure 3

(A–C) Histological examination of the left ventricular (LV) myocardium. Masson's blue trichrome; bar=20 μm. In the control group (A), normal structure of the myocardium was observed. In the DAU group (B), foci of cardiomyocytes showing profound degeneration (asterisks) were found. Marked morphological changes comprise cytoplasmic vacuolisation, cell swelling and loss of myofibrils resulting in cell death with subsequent development of interstitial fibrosis (arrow). The LV myocardium of DEX co-treated animals (C) showed largely preserved normal morphology with only subtle changes; signs of cardiomyocyte degeneration were scarce (asterisk).

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