Figure 4 | British Journal of Cancer

Figure 4

From: Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death

Figure 4

Terminal deoxynucleotidyl transferase biotin-dUTP nick end labelling (TUNEL) assay. (A–C) Representative samples of left ventricular (LV) myocardium labelled with TUNEL in the control (A), DAU (B) and DEX+DAU (C) groups. The arrows indicate examples of TUNEL-positive nuclei; bar=20 μm. (D) Quantitative analysis of TUNEL assay. Statistical significance (ANOVA, P<0.05) in comparison with ‘d’ daunorubicin group. (E) Scatterplot of the LV fractional shortening vs number of TUNEL-positive nuclei per square millimetre and results of the Spearman's correlation analyses.

Back to article page