Figure 1

Effect of IMiDs on cell growth parameters. CT26 cells were cultured continuously with thalidomide, lenalidomide or pomalidomide (0–30 μ M) for 3 days. Changes in cell numbers were assessed by the MTT assay and are represented by values normalised to control samples with no treatment (A). The effect on cell cycle distribution was also assessed (B). Each data point represents the mean and s.d. (where appropriate) of at least three separate experiments.