Figure 6

Effect of the IMiDs on pulmonary metastases. CT26 cells were injected into the tail vein of BALB/c mice. The effect of thalidomide, lenalidomide and pomalidomide administered daily IP on pulmonary metastases was assessed on day 14 (A). There were significantly fewer metastatic nodules in the lungs resected from treated animals (P<0.001 vs controls). Representative lungs are also shown. Similar reductions in metastatic nodules of CMT93 were observed in mice treated with the drugs (B). Each data point represents the means and ranges of five animals. The effect on metastasis of pre-treating CT26 cells for 3 days with 10μ M lenalidomide was also studied (C), where the shaded bars indicate treatment with lenalidomide. Pre-treatment (treatment protocol C) resulted in fewer nodules.