Table 2a Analysis of 5-year distant metastases according to the origin of the patients and period of surgery
From: Impact of tumour size on axillary involvement and distant dissemination in breast cancer
Total ( n =18159 patients) | IGR 1954–1983 (3661) | SG 1976–1990 (6778) | SG 1991–1999 (7720) | P -values* |
|---|---|---|---|---|
Geometric mean tumour diameter (mm) | 22.0 | 18.0 | 16.0 | <10−10/<10−10 |
Absolute risk of distant metastases at 5 years (95% CI) | 20.8% (19.5–22.2) | 15.2% (14.4–16.0) | 9.5% (8.8–10.2) | <10−10/<10−10 |
Relative risks of metastases (95% CI) | 1.42 (1.29–1.56) | 1 (reference) | 0.61 (0.55–0.67) | <10−10/<10−10 |
Probit analysis: estimated tumour volume (ml) corresponding to 50% of patients with metastases at 5 years (diameter mm) | 237 ml (77 mm) | 305 ml (83 mm) | 985 ml (123 mm) | 0.07/<10−10 |
Probability of metastases for a 18-mm tumour (+) (%) | 16.2 | 14.8 | 9.5 | |
Odds ratio (logistic regression) adjusted on continuous tumour size (95% CI) | 1.11 (0.99–1.23) | 1 (Reference) | 0.60 (0.54–0.67) | 0.07/<10−10 |
Relative risks (Cox's model) adjusted on continuous tumour size (95% CI) | 1.09 (0.99–1.20) | 1 (Reference) | 0.63 (0.57–0.69) | 0.07/<10−10 |
Relative risks (Cox's model) adjusted on tumour size category (<30 vs ⩾30 mm) (95% CI) | 1.29 (1.17–1.41) | 1 (Reference) | 0.61 (0.55–0.67) | 10−7/<10−10 |
