Table 2b Analysis of nodal involvement according to the origin of the patients and period of surgery
From: Impact of tumour size on axillary involvement and distant dissemination in breast cancer
Total ( n =18 159 patients) | IGR 1954–1983 ( n =3661) | SG 1976–1990 ( n =6778) | SG 1991–1999 ( n =7720) | P -values* |
|---|---|---|---|---|
Geometric mean tumour diameter (mm) | 22.0 | 18.0 | 16.0 | <10−10/<10−10 |
Patients with node positive disease (%) | 56.3 | 34.6 | 34.3 | <10−10/0.73 |
Probit analysis: tumour volume (ml) corresponding to 50% of patients with involved nodes (diameter mm) | 10.7 ml (27.4 mm) | 13.8 ml (29.8 mm) | 17.7 ml (32.3 mm) | 0.03/0.01 |
Probability of node involvement for an 18-mm tumour (+) (%) | 37.9 | 35.6 | 33.4 | |
Odds ratio (logistic regression), adjusted on tumour size and the number of sampled nodes (95% CI) | 1.13 (1.03–1.24) | 1 (Reference class) | 0.91 (0.84–0.98) | 0.01/0.01 |
