Table 5 Associations between polymorphisms and overall haematological, gastrointestinal and neurological toxicity

From: Molecular markers of response and toxicity to FOLFOX chemotherapy in metastatic colorectal cancer

 

Haematological

Gastrointestinal

Neurological

 

0–2

3–4

 

0–2

3–4

 

0–2

3–4

 

Genotype

n

%

n

%

P

n

%

n

%

P

n

%

n

%

P

MTHFR 677

 CC

24

56

19

44

 

37

86

6

14

 

33

77

10

23

 

 CT

40

74

14

26

 

50

93

4

7

 

49

91

5

9

 

 TT

12

63

7

37

0.17

14

74

5

26

0.10

14

74

5

26

0.10

ERCC1–118

 CC

7

70

3

30

 

10

100

0

0

 

9

90

1

10

 

 CT

43

67

21

33

 

56

88

8

12

 

55

86

9

14

 

 TT

25

61

16

39

0.77

35

85

6

15

0.44

33

81

8

19

0.66

XRCC1–399

 GG

9

60

6

40

 

13

87

2

13

 

15

100

0

0

 

 AG

41

67

20

33

 

53

87

8

13

 

49

80

12

20

 

 AA

25

64

14

36

0.86

35

90

4

10

0.90

33

85

6

15

0.17

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