Table 2 Grade ⩾3 drug-related adverse events and dose-limiting toxicities

From: Weekly administration of sagopilone (ZK-EPO), a fully synthetic epothilone, in patients with refractory solid tumours: results of a phase I trial

Adverse event

0.6 mg m−2, n (n =9)

4.0 mg m−2, n (n =3)

5.3 mg m−2, n (n =7)

7.0 mg m−2, n (n =4)

Overall, n (n =23)

Peripheral neuropathy

  

1

1a

2 (9)

Diarrhoea

   

1a

1 (4)

Fatigue

   

1

1 (4)

Increased γ-GT

   

1b

1 (4)

Lymphopenia

1

   

1 (4)

Thrombocytopenia

1

   

1 (4)

  1. a Dose-limiting toxicities; all events grade 3 except grade 4.
  2. b Grade 4.
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