Table 1 Univariate associations of variables with relapse-free survival within colon cancer, TNM stages II and III

	No.	Relapse	5-year relapse- free survival (%)	s.e. (%)	P -value
Age					NS
⩽60 years	113	33	71	4
>60 years	177	52	71	4
Sex					NS
Women	152	48	69	4
Men	138	37	73	4
TNM stage					<0.001
Stage II	185	31	83	3
Stage III	105	54	48	5
Randomisation group ^a					NS
Adjuvant therapy	149	41	73	4
Surgery alone	141	44	68	4
Randomisation group ^b					0.012
Adjuvant therapy	54	23	58	7
Surgery alone	51	31	37	7
Ki-67					0.001
⩽40%	134	54	60	4
>40%	129	26	80	4
EZH2					0.041
Index 0–3	200	68	66	3
Index 4–9	41	7	82	6
Histological type					NS
Adenocarcinoma	250	74	70	3
Variant^c	32	6	80	7
Histological grade					0.025
High/moderate	228	62	73	3
Poor differentiation	56	22	59	7
Tumour localisation					NS
Proximal colon	161	41	74	4
Distal colon	129	44	67	4

Abbreviations: EZH2=enhancer of zeste homologue 2; NS=not significant; TNM=tumor–node–metastasis.
^aIncluding both TNM stages II and III.
^bIncluding TNM stage III.
^cVariant histology includes mucinous and signet-ring carcinomas.

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