Table 1 Statistical significance of associations between molecular variables

From: Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer

Variable

HIF-2 α

CA9

VEGF

Dll4 Endo.

PHD1

PHD2

PHD3

HIF-1α

χ 2

<0.01

3.43

0.96

2.08

0.23

<0.01

<0.01

 

P

1.00

0.09

0.33

0.11

0.63

0.97

1.00

HIF-2α

χ 2

—

<0.01

18.78

4.5

4.24

10.41

11.75

 

P

 

0.96

<0.0001

0.03*,a

0.04*

0.001

<0.001

CA9

χ 2

—

 

<0.01

<0.01

1.45

4.53

1.11

 

P

  

1.00

1.00

0.23

0.03*

0.29

VEGF

χ 2

—

—

—

5.98

34.15

25.33

29.92

 

P

   

0.01

<0.0001

<0.0001

<0.0001

Dll4 Endo.

χ 2

—

—

—

—

5.43

0.26

7.14

 

P

    

0.01

0.61

0.008

PHD1

χ 2

—

—

—

—

—

16.04

32.90

 

P

     

<0.0001

<0.0001

PHD2

χ 2

—

—

—

—

—

—

13.85

 

P

      

0.0002

  1. Negative association.
  2. All associations are positive unless otherwise stated.
  3. *These P-values are not significant after correction for multiple testing by the Benjamini and Hochberg false discovery rate controlling procedure with a cutoff=0.05.
  4. Abbreviations: Endo.=endothelial; PHD1=prolyl hydroxylase; VEGF=vascular endothelial growth factor; CA9=carbonic anhydrase 9; HIF=hypoxia-inducible factor; Dll4=delta-like ligand 4.
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