Table 3 Age-adjusted and multivariate rate ratios for total, localised, advanced and fatal prostate cancer according to lifetime (age 30 and 50 years and current age) work or occupational activity levels

	Lifetime average work or occupational activity levels
	Mostly sitting	Sitting half of the time	Mostly standing	Heavy manual labour	P -trend
Total-incidence prostate cancer
No. of cases	291	405	1141	111
Age-adjusted RR (95% CI)	1	0.81 (0.69–0.94)	0.80 (0.70–0.91)	0.72 (0.58–0.89)	0.003
Multivariate RR (95% CI)^a	1	0.80 (0.69–0.93)	0.79 (0.69–0.91)	0.72 (0.57–0.90)	0.007
Localised
No. of cases	123	184	439	36
Age-adjusted RR (95% CI)	1	0.86 (0.68–1.08)	0.71 (0.58–0.87)	0.55 (0.38–0.79)	<0.001
Multivariate RR (95% CI)^a	1	0.87 (0.69–1.09)	0.72 (0.58–0.90)	0.55 (0.38–0.82)	<0.001
Advanced
No. of cases	96	129	422	39
Age-adjusted RR (95% CI)	1	0.75 (0.57–0.97)	0.85 (0.68–1.07)	0.75 (0.52–1.10)	0.546
Multivariate RR (95% CI)^a	1	0.74 (0.56–0.97)	0.88 (0.69–1.12)	0.79 (0.54–1.18)	0.853
Fatal prostate cancer
No. of cases	16	21	82	8
Age-adjusted RR (95% CI)	1	0.65 (0.34–1.25)	0.86 (0.50–1.48)	0.84 (0.36–1.97)	0.814
Multivariate RR (95% CI)^a	1	0.64 (0.33–1.23)	0.88 (0.49–1.58)	0.89 (0.36–2.17)	0.679

Abbreviations: CI, confidence interval; RR, rate ratio.
^aMultivariate RRs were adjusted for lifetime average walking or bicycling levels (hardly ever, <20, 20–40, 41–60 and >60 min per day), age (years, continuous), waist–hip ratio (quartiles), height (continuous), diabetes (yes or no), alcohol consumption (current drinker, former drinker and never drinker), smoking status (current smoker, former smoker and never smoked), years of education (1–9 years, 9–12 years, more than 12 years), total energy intake (calories, continuous), consumption of dairy product (times per day, continuous) and red meat (times per day, continuous) and parental history with respect to prostate cancer (yes, no or not known). A complete-subjects analysis automatically discarded missing values on any covariate.

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