Figure 2
Baseline and post-treatment magnetic resonance imaging of a representative, responding glioblastoma patient including post-contrast axial T1-weighted and fluid-attenuated inversion recovery (FLAIR) images. [18F]fluorodeoxyglucose positron-emission tomography imaging at the completion of 12 cycles of therapy shows no evidence of hypermetabolic activity (arrow). (A) Baseline and off-study magnetic resonance imaging showing worsened FLAIR signal abnormality, indicating an infiltrative, microscopic pattern of treatment failure (arrows) involving the isolateral hemisphere (B) and the contralateral hemisphere (C), despite improved contrast enhancement.
