Table 2 Sensitivity analyses for the linear decision analytical model in the United Kingdom, Germany, France and Italy
Sunitinib costs | Bevacizumab + IFN costs | Cost savings (%) | |
|---|---|---|---|
United Kingdom | |||
Hospitalisation cost | |||
Reduction 10% | €2202 | €1230 | €972 (44) |
Increase 10% | €2497 | €1391 | €1106 (44) |
Exclude main sunitinib adverse event | |||
Lymphopaenia | €2081 | €1309 | €772 (37) |
Thrombocytopaenia | €2040 | €1239 | €801 (39) |
Both adverse events | €1771 | €1239 | €532 (30) |
Exclude main bevacizumab + IFN adverse event | |||
Proteinuria | €2305 | €1023 | €1282 (56) |
Fatigue and asthaenia | €2097 | €1067 | €1030 (49) |
Both adverse events | €2097 | €780 | €1317 (63) |
Germany | |||
5% increase ambulatory treatment | €2085 | €1482 | €603 (29) |
Value of points | |||
Three points | €2030 | €1461 | €569 (28) |
Six points | €2275 | €1555 | €720 (32) |
Hospitalisation cost | |||
Reduction 10% | €1893 | €1340 | €553 (29) |
Increase 10% | €2250 | €1613 | €637 (28) |
Exclude main sunitinib adverse event | |||
Neutropaenia | €1749 | €1380 | €369 (21) |
Lymphopaenia | €1756 | €1477 | €2279 (16) |
Both adverse events | €1434 | €1380 | €54 (4) |
Exclude main bevacizumab + IFN adverse event | |||
Fatigue and asthaenia | €1848 | €1054 | €794 (43) |
GI perforation | €2071 | €1358 | €713 (34) |
Both adverse events | €1848 | €935 | €913 (49) |
France | |||
Hospitalisation cost | |||
Reduction 10% | €4867 | €1795 | €3073 (63) |
Increase 10% | €5386 | €2118 | €3267 (61) |
Exclude main sunitinib adverse event | |||
Anaemia | €3926 | €1730 | €2196 (56) |
Neutropaenia | €4296 | €1764 | €2531 (59) |
Both adverse events | €3096 | €1538 | €1558 (50) |
Exclude main bevacizumab + IFN adverse event | |||
Fatigue/asthaenia | €4896 | €1521 | €3375 (69) |
Anaemia | €3926 | €1730 | €2196 (56) |
Both adverse events | €3696 | €1294 | €2402 (65) |
Italya | |||
Hospitalisation cost | |||
Reduction 10% | €802 | €362 | €441 (55) |
Increase 10% | €981 | €442 | €538 (55) |
Exclude main sunitinib adverse event | |||
Lymphopaenia | €675 | €402 | €273 (40) |
Hypertension | €750 | €349 | €401 (54) |
Both adverse events | €533 | €349 | €184 (35) |
Exclude main bevacizumab + IFN adverse event | |||
Venous thrombosis | €891 | €330 | €561 (63) |
Fatigue/asthaenia | €858 | €334 | €524 (61) |
Both adverse events | €858 | €263 | €595 (69) |