Table 2 Sensitivity analyses for the linear decision analytical model in the United Kingdom, Germany, France and Italy

From: Costs of managing adverse events in the treatment of first-line metastatic renal cell carcinoma: bevacizumab in combination with interferon-α2a compared with sunitinib

 

Sunitinib costs

Bevacizumab + IFN costs

Cost savings (%)

United Kingdom

Hospitalisation cost

Reduction 10%

€2202

€1230

€972 (44)

Increase 10%

€2497

€1391

€1106 (44)

Exclude main sunitinib adverse event

Lymphopaenia

€2081

€1309

€772 (37)

Thrombocytopaenia

€2040

€1239

€801 (39)

Both adverse events

€1771

€1239

€532 (30)

Exclude main bevacizumab + IFN adverse event

Proteinuria

€2305

€1023

€1282 (56)

Fatigue and asthaenia

€2097

€1067

€1030 (49)

Both adverse events

€2097

€780

€1317 (63)

Germany

5% increase ambulatory treatment

€2085

€1482

€603 (29)

Value of points

Three points

€2030

€1461

€569 (28)

Six points

€2275

€1555

€720 (32)

Hospitalisation cost

Reduction 10%

€1893

€1340

€553 (29)

Increase 10%

€2250

€1613

€637 (28)

Exclude main sunitinib adverse event

Neutropaenia

€1749

€1380

€369 (21)

Lymphopaenia

€1756

€1477

€2279 (16)

Both adverse events

€1434

€1380

€54 (4)

Exclude main bevacizumab + IFN adverse event

Fatigue and asthaenia

€1848

€1054

€794 (43)

GI perforation

€2071

€1358

€713 (34)

Both adverse events

€1848

€935

€913 (49)

France

Hospitalisation cost

Reduction 10%

€4867

€1795

€3073 (63)

Increase 10%

€5386

€2118

€3267 (61)

Exclude main sunitinib adverse event

Anaemia

€3926

€1730

€2196 (56)

Neutropaenia

€4296

€1764

€2531 (59)

Both adverse events

€3096

€1538

€1558 (50)

Exclude main bevacizumab + IFN adverse event

Fatigue/asthaenia

€4896

€1521

€3375 (69)

Anaemia

€3926

€1730

€2196 (56)

Both adverse events

€3696

€1294

€2402 (65)

Italya

Hospitalisation cost

Reduction 10%

€802

€362

€441 (55)

Increase 10%

€981

€442

€538 (55)

Exclude main sunitinib adverse event

Lymphopaenia

€675

€402

€273 (40)

Hypertension

€750

€349

€401 (54)

Both adverse events

€533

€349

€184 (35)

Exclude main bevacizumab + IFN adverse event

Venous thrombosis

€891

€330

€561 (63)

Fatigue/asthaenia

€858

€334

€524 (61)

Both adverse events

€858

€263

€595 (69)

  1. Abbreviations: GI=gastrointestinal; IFN=interferon-α2a.
  2. aOn the basis of costs of managing grade 3–4 costs only.