Figure 4
From: Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro
MAD2 down-regulation alters the protein secretion of cells and enhances cell migration. (A) (Panel a) ELISA analysis shows a three-fold increase in IL-6 levels in the MAD2↓ cells compared with the scramble (P<0.005) and the untransfected (P<0.001) controls. (Panel b) MAD2↓ cells show a higher expression of IL-8 compared with the controls. However, this increase reaches statistical significance only in comparison with the untransfected control (P=0.01). (B) MAD2↓ cells show a higher migration ability compared with the untransfected (P<0.01) and scramble (P<0.05) controls. Mean values were compared using the t-test assuming equal variances.
