Figure 1
Unlocalised and localised MRS spectra of patient 30. Unlocalised MRS spectra acquired from patient 30 (GIST measuring 62 × 60 × 55 mm) at (A) 1.4 h; (B) 16.1 h and (C) 19.4 h following the end of the SR4554 infusion (2600 mg m−2). Localised MRS spectra were acquired at (D) 1.8 h; (E) 16.4 h and (F) 19.7 h following the end of the infusion. In the localised studies, the images in each panel in panels D–F show different views of the tumour studied, and the highlighted volume (voxel) in each image shows the part of the tumour from where the MRS spectrum was acquired. The timings of ∼16 and ∼20 h post infusion (at the time of MRS no. 2 and MRS no. 3 respectively) are equivalent to approximately 5.5 × and 6.5 × the half-life of SR4554 in this patient, respectively.
