Table 4 Adverse reactions in all phase II 215 treatment courses
From: Phase I/II study of sequential therapy with irinotecan and S-1 for metastatic colorectal cancer
Grade of toxicity | ||||||
|---|---|---|---|---|---|---|
Toxicity ( n =215) | 1 | 2 | 3 | 4 | All grades (%) | Grades 3 and 4 (%) |
Haematological | ||||||
Leucopaenia | 5 | 41 | 3 | 0 | 22.8 | 1.4 |
Neutropaenia | 11 | 50 | 14 | 0 | 34.9 | 6.5 |
Anaemia | 15 | 29 | 2 | 0 | 21.4 | 0.9 |
Non-haematological | ||||||
Anorexia | 12 | 14 | 3 | 0 | 13.5 | 1.4 |
Nausea | 11 | 8 | 1 | 0 | 9.3 | 0.5 |
Vomiting | 13 | 4 | 1 | 0 | 8.4 | 0.5 |
Diarrhoea | 18 | 20 | 2 | 0 | 18.6 | 0.9 |
Stomatitis | 19 | 3 | 0 | 0 | 10.2 | 0 |
Constipation | 1 | 0 | 0 | 0 | 0.5 | 0 |
Ileus | 0 | 0 | 1 | 0 | 0.5 | 0.5 |
Fever | 1 | 0 | 0 | 0 | 0.5 | 0 |
General fatigue | 6 | 6 | 1 | 0 | 6.1 | 0.5 |
Rash | 0 | 3 | 0 | 0 | 1.4 | 0 |
Tearing | 3 | 3 | 0 | 0 | 2.8 | 0 |
Alopecia | 139 | 0 | 0 | 0 | 64.7 | 0 |
Bilirubin | 20 | 4 | 0 | 0 | 11.2 | 0 |
GOT | 40 | 1 | 0 | 0 | 19.1 | 0 |
GPT | 35 | 3 | 0 | 0 | 17.7 | 0 |
