Table 2 Association of EGFRa and phospho-EGFR expression with clinicopathologic variables

From: Prognostic effect of activated EGFR expression in human colon carcinomas: comparison with EGFR status

 

Phospho-EGFR intensity ( N =388)

EGFR intensity ( N =361)

Characteristic

Absent (0) ( N =231)

Weak/Moderate (1+, 2+) ( N =157)

P -value b

Other (0, 1+, 2+) ( N =301)

Strong (3+) ( N =60)

P -value b

Age (years)

 ⩽65

123 (53%)

93 (59%)

0.24

179 (60%)

29 (48%)

0.11

 >65

108 (47%)

64 (41%)

 

122 (40%)

31 (52%)

 

Gender

 Female

107 (46%)

78 (50%)

0.52

142 (47%)

31 (52%)

0.52

 Male

124 (54%)

79 (50%)

 

159 (53%)

29 (48%)

 

Tumour site

 Proximal

111 (48%)

87 (55%)

0.15

134 (45%)

33 (55%)

0.14

 Distal

120 (52%)

70 (45%)

 

167 (55%)

27 (45%)

 

Histological grade c

 1, 2

146 (63%)

107 (68%)

0.32

217 (72%)

37 (62%)

0.11

 3, 4

85 (37%)

50 (32%)

 

84 (28%)

23 (38%)

 

Lymph nodes

 0

41 (18%)

36 (26%)

0.14

80 (27%)

8 (13%)

0.09

 1–3

86 (38%)

42 (30%)

 

142 (47%)

32 (53%)

 

 >3

98 (44%)

60 (44%)

 

79 (26%)

20 (33%)

 

TNM

 II

41 (18%)

36 (23%)

0.21

80 (27%)

8 (13%)

0.03

 III

190 (82%)

121 (77%)

 

221 (73%)

52 (87%)

 

MMR status

 Intact MMR

189 (91%)

116 (88%)

0.38

273 (91%)

54 (90%)

0.81

 Defective MMR

19 (9%)

16 (12%)

 

27 (9%)

6 (10%)

 

Ki-67

 Median (range)

15.7 (0.0–82.0)

26.2 (0.6–89.2)

0.015d,e

19.6 (0.0–89.2)

42.3 (1.7–85.8)

0.0002d

 Mean (s.d.)

24.3 (21.7)

31.4 (22.8)

 

25.6 (21.9)

39.0 (24.9)

 

Caspase-3

 Median (range)

0.0 (0.0–20.0)

0.0 (0.0–46.0)

0.24d,e

0.0 (0.0–35.0)

1.5 (0.0–46.0)

0.13d

 Mean (s.d.)

2.1 (3.6)

3.9 (7.8)

 

2.7 (5.1)

3.9 (7.4)

 

Caspase-3 : Ki-67 ratio

 Median (range)

0.0 (0.0–0.4)

0.0 (0.0–0.4)

0.54d,f

0.0 (0.0–1.4)

0.0 (0.0–0.3)

0.31d

 Mean (s.d.)

0.0 (0.1)

0.0 (0.1)

 

0.0 (0.1)

0.0 (0.1)

 
  1. Abbreviations: EGFR, epidermal growth factor receptor; MMR, mismatch repair.
  2. aData are for membranous EGFR staining.
  3. bChi-square P-value.
  4. c1, 2 (well/moderate); 3, 4 (poor/undifferentiated).
  5. dWilcoxon's rank-sum P-value.
  6. e190 cases with p-EGFR and Ki67, caspase-3.
  7. f189 cases with p-EGFR and caspase-3 : Ki67 ratio.
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