Figure 6
From: Prostate cancer cells modulate osteoblast mineralisation and osteoclast differentiation through Id-1
Factors other than TNF-β might also be involved in Id-1-modulated prostate cancer-mediated bone cell differentiation. IL-6 mRNA expression is positively correlated with Id-1 expression in LNCaP and PC3 (A), and Id-1 is also positively correlated with IL-6 expression in primary prostate specimens (B). (C) Promoter assay shows that IL-6 promoter activity was not modulated by reduced expression of Id-1. Columns represent the mean values from three independent experiments±s.d. (D) Patients with high level of IL-6 staining in their primary prostate cancer had a higher risk of developing distant metastases. (E) A similar result was obtained when only patients with high Gleason score (⩾7) were analysed.
