Table 3a Antibody-based VEGFi and imaging biomarkers

From: Biomarkers of angiogenesis and their role in the development of VEGF inhibitors

References

Drug, disease and trial

DCE-MRI biomarkers

N

Drug-induced changes

Prognostic and predictive values

Overmoyer et al (2004)

Docetaxel±Bevacizumab

Breast cancer; Phase 2

kep

26

↓kep

NS

Wedam et al (2006)

Bevacizumab

Breast cancer; Phase 2

Ktrans, ve

20

↓Ktrans

NS

Jayson et al (2005)

HuMV833 (Anti-VEGF)

Advanced cancer; Phase 1

Ktrans kep rBV

20

↓kep

NS

Ton et al (2007)

CDP791 (Anti-VEGFR-2)

Advanced Cancer; Phase 1

Ktrans

31

No DCE-MRI change

Dose-related volumetric change

NS

  1. Abbreviations: VEGF=vascular endothelial growth factor; DCE-MRI=dynamic contrast-enhanced magnetic resonance imaging; kep=rate constant; Ktrans=bi-directional transfer coefficient; rBV=regional blood volume; ve=volume of the extravascular extracellular space (EES).
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