Table 2 ALDH1 expression and associations with clinicopathological features and molecular characteristics
Variable | ALDH1 negative ( n; %); n =95 | ALDH1 positive ( n; %); n =88 | OR (95% CI) | P -value |
|---|---|---|---|---|
Age in years | ||||
 <50 | 52 (52) | 48 (48) | 1.0 | |
 ⩾50 | 37 (49) | 38 (51) | 1.1 (0.6–2.0) | NS |
Duration of symptoms | ||||
 ⩽9 months | 26 (41) | 37 (59) | 1.0 | |
 >9 months | 35 (60) | 23 (40) | 0.5 (0.2–1.0) | 0.036 |
Histological type | ||||
 Ductal | 82 (51) | 79 (49) | 1.0 | |
 Others | 13 (62) | 8 (38) | 1.6 (0.6–4.0) | NS |
Histological grade | ||||
 Grade 1 | 20 (87) | 3 (13) | 1.0 | |
 Grade 2 | 38 (59) | 26 (41) | 4.6 (1.2–16.9) | 0.016 |
 Grade 3 | 37 (39) | 58 (61) | 10.5 (2.9–37.6) | 0.000 |
Nuclear grade | ||||
 Grade 1 | 18 (72) | 7 (28) | 1.0 | |
 Grade 2 | 48 (63) | 28 (37) | 1.5 (0.6–4.0) | NS |
 Grade 3 | 29 (36) | 52 (64) | 4.6 (1.7–12.3) | 0.001 |
Mitotic count | ||||
 0–6 | 31 (71) | 13 (29) | 1.0 | |
 7–13 | 29 (67) | 14 (33) | 1.5 (0.5–2.9) | NS |
 >13 | 35 (37) | 60 (63) | 3.3 (1.9–8.8) | 0.000 |
Ki-67 | ||||
 Low (<20%) | 50 (57) | 38 (43) | 1.0 | |
 High (⩾20%) | 45 (47) | 50 (53) | 1.4 (0.8–2.6) | NS |
p53 | ||||
 Low SI (0–4) | 73 (57) | 55 (43) | 1.0 | |
 High SI (>4) | 22 (40) | 33 (60) | 2.0 (1.05–4.8) | 0.034 |
ER | ||||
 Positive | 48 (69) | 22 (31) | 1.0 | |
 Negative | 47 (42) | 66 (58) | 3.1 (1.6–5.7) | 0.000 |
PR | ||||
 Positive | 35 (67) | 17 (33) | 1.0 | |
 Negative | 60 (46) | 71 (54) | 2.4 (1.2–4.7) | 0.009 |
HER2 | ||||
 Negative | 82 (54) | 71 (46) | 1.0 | |
 Positive | 13 (43) | 17 (57) | 1.5 (0.7–3.3) | NS |
