Table 1 Literature review over miRNA quantitative RT–PCR studies in thyroid tumours

From: Differential miRNA expression profiles in variants of papillary thyroid carcinoma and encapsulated follicular thyroid tumours

Material, Total sample

Tumour type/normal thyroid

Deregulated miRNA

Reference

Fresh-frozen tissue, n=10

Matched pairs of 5 PTCs and 5 normal thyroids

miRNAs 221, 222 and 146b upregulated in PTC vs normal thyroid

He et al (2005)

Snap-frozen tissue, n=9

5 FTCs

4, FAs

4, normal thyroids

miRNAs 197 and 56 upregulated in FTC vs FA

Weber et al (2006)

Fresh frozen tissue, n=47

8 FAs and

39 PTCs

Precursor miRNAs 221, 222 and 181b-1 upregulated in PTC vs FA

Pallante et al (2006)

Formalin-fixed paraffin-embedded tissue, n=20

10 PTCs (conventional variant) and

10 MNGs

miRNAs 21, 31, 221 and 222 upregulated in PTC vs MNG

Tetzlaff et al (2007)

Fresh-frozen and formalin-fixed paraffin-embedded tissue, n=20

20 ATCs

miRNAs 30d, 125b, 26 and 30-a-5p downregulated in ATC vs normal thyroid

Visone et al (2007)

Snap-frozen tissue, n=60

23 PTCs (18 conventional and 5 follicular variants)

9 FTCs,

8 FAs,

4 ACs,

4 PDCs,

2 MCs,

5 normal thyroids and

5 hyperplastic nodules

miRNAs 187, 221, 222, 181b, 146b, 155 and 224 upregulated in follicular cell-derived carcinomas with high variance between tumour type; miRNAs 187, 221, 222, 146b and 155 upregulated in PTC with strong relationship to mutational status

Nikiforova et al (2008)

Formalin-fixed paraffin-embedded tissue, n=74

32 PTCs (27 conventional and 5 follicular variants)

24 FAs,

10 ‘borderline’ follicular lesions,

11 hyperplastic nodules,

2 FTCs and

5 normal thyroid

miRNA 146 upregulated in PTC vs non-papillary carcinomas; miRNAs 221 and 222 upregulated in PTC vs FA, hyperplastic nodules, normal thyroid but with substantial overlaps in individual cases; miRNA 146b indistinguishable between ‘borderline’ tumours and FA and lower than in PTC

Chen et al (2008)

Formalin-fixed paraffin-embedded tissue, n=113

50 PTCs (10 conventional, 10 tall cell and 30 follicular variants)

22 WDT-UMPs,

21 FTCs

10 FAs and

10 MNGs

Mean values of miRNAs 146b, 181b, 21, 221 and 222 upregulated in PTC; miRNA 146b upregulated in PTC-CT/PTC-TCV vs MNG/FA; substantial overlaps of all miRNAs in follicular cell-derived tumours; intermediate miRNA expression profile of PTC-FV

Our study

  1. Abbreviations: PTC=papillary thyroid carcinoma; FTC=follicular thyroid carcinoma; FA=follicular adenoma; MNG=multinodular goitre; ATC/AC=anaplastic carcinoma; PDC=poorly differentiated carcinoma; MC=medullary carcinoma; WDT-UMP=well-differentiated tumour of unknown malignant potential.
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