Figure 5

Effects of EG3287 on A549 cell survival in the presence of chemotherapeutic drugs and fibronectin. (A) A549 cells were seeded on non-coated or fibronectin (Fib)-coated 96-well plates in serum-free medium in the absence or presence of 100 μ M EG3287 and cell viability was measured after 48 h of treatment. ^**P<0.01 vs non-coated control; ^††P<0.01 vs untreated control. (B, C) A549 cells were seeded on non-coated or fibronectin-coated 96-well plates in serum-free medium containing 5-FU or paclitaxel at the indicated concentrations in the absence or presence of 100 μ M EG3287. ^**P<0.01 vs non-coated control; ^†P<0.05; ^††P<0.01 for 5-FU or paclitaxel plus EG3287 vs 5-FU or paclitaxel alone on fibronectin.