Table 1 Study characteristics of the breast cancer clinical and pathological variables grouped by deprivation 1–9 and 10 and by p53 mutation status

From: p53 mutation, deprivation and poor prognosis in primary breast cancer

		p53m						p53WT
		Deprivation 1–9			Deprivation 10			Deprivation 1–9			Deprivation 10
	Total	N	%	χ ²	N	%	χ ²	N	%	χ ²	N	%	χ ²
Total number	246	54	—	—	10	—	—	175	—	—	7	—	—
Alive	205	39	72.2	−0.80	3	30.0	−3.41	156	89.1	+0.71	7	100.0	+0.23
Dead	41	15	27.8	+4.00	7	70.0	+17.07	19	10.9	−3.54	0	0.0	−1.17
Disease free	184	32	59.3	−1.74	2	20.0	−4.01	143	81.7	+1.12	7	100.0	+0.59
Recurred	62	22	40.7	+5.17	8	80.0	+11.91	32	18.3	−3.32	0	0.0	−1.76
Tumour grade
1	34	0	0.0	−7.41	0	0.0	−1.45	31	18.7	+1.96	3	42.9	+3.87
2	91	9	17.6	−5.92	1	10.0	−2.15	80	48.2	+3.69	1	14.3	−1.09
3	109	42	82.4	+14.01	9	90.0	+4.05	55	33.1	−6.45	3	42.9	−0.02
Not known	12	—	—	—	—	—	—	—	—	—	—	—	—
Tumour size
<2 cm	170	34	65.4	−0.18	8	80.0	+0.14	122	70.5	+0.00	6	85.7	+0.24
⩾2 cm	72	18	34.6	+0.41	2	20.0	−0.32	51	29.5	−0.00	1	14.3	−0.56
Not known	4	—	—	—	—	—	—	—	—	—	—	—	—
ER+	175	24	44.4	−5.50	5	50.0	−0.64	140	80.5	+1.99	6	85.7	+0.20
ER−	70	30	55.6	+13.76	5	50.0	+1.61	34	19.5	−4.97	1	14.3	−0.50
Not known	1	—	—	—	—	—	—	—	—	—	—	—	—
HER2+	33	14	28.6	+6.91	2	20.0	+0.22	13	7.9	−4.81	4	66.7	+11.45
HER2−	197	35	71.4	−1.16	8	80.0	−0.04	152	92.1	+0.81	2	33.3	−1.92
Not known	16	—	—	—	—	—	—	—	—	—	—	—	—
TrNeg	45	17	34.7	+5.73	4	40.0	+2.13	24	14.5	−2.13	0	0.0	−1.17
Not TrNeg	185	32	65.3	−1.39	6	60.0	−0.52	141	85.5	+0.52	6	100.0	+0.29
Not known	16	—	—	—	—	—	—	—	—	—	—	—	—
Node+	117	35	64.8	+3.38	6	60.0	+0.33	74	42.3	−1.02	2	28.6	−0.53
Node−	129	19	35.2	−3.07	4	40.0	−0.30	101	57.7	+0.93	5	71.4	+0.48
Age (years)
<40	14	4	7.4	+0.28	0	0.0	−0.57	8	4.6	−0.39	2	28.6	+6.44
40–49	34	10	18.5	+0.86	2	20.0	+0.28	21	12.0	−0.42	1	14.3	+0.00
50–59	69	13	24.1	−0.30	3	30.0	+0.01	51	29.1	+0.07	2	28.6	+0.00
⩾60	129	27	50.0	−0.06	5	50.0	−0.01	95	54.3	+0.11	2	28.6	−0.76
Median age (years)	61.30	58.79 (28.72–88.48)			61.15 (43.58–84.25)			61.94 (33.53–88.99)			55.51 (39.69–87.78)
Median FU (years)	4.96	4.94 (0.06–8.47)			2.44 (0.41–6.42)			4.96 (0.10–10.00)			7.20 (5.02–8.70)
Median DF (years)	4.74	4.10 (0.02–8.47)			2.02 (0.02–6.42)			4.83 (<0.01–9.29)			7.20 (5.02–8.70)

Abbreviations: DF=disease-free survival; ER=oestrogen receptor; FU=follow-up.
Percentages may not sum to 100 due to rounding. The χ² score, calculated across all four p53/deprivation categories, indicates the deviation of the observed from the expected frequency, in which a high score signifies a large deviation and a χ² score greater than unity is deemed ‘of interest’, and highlighted in bold type. The χ² score is marked with a ‘+’ if the observed frequency exceeds the expected, and with a ‘−’ otherwise. Median ages and follow-up were not significantly different for any of the patient groupings (p⩾0.342 in all cases; two-sample t-test and Mann–Whitney U-test).

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Table 1 Study characteristics of the breast cancer clinical and pathological variables grouped by deprivation 1–9 and 10 and by p53 mutation status

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