Table 1 Odds ratios (ORs) (95% confidence intervals, CIs) of breast cancer associated with bisphosphonate use
From: Bisphosphonates for osteoporosis treatment are associated with reduced breast cancer risk
Cases ( N =2936) | Controls ( N =2975) | Age adjusted | Multivariable adjusted | |
|---|---|---|---|---|
Bisphosphonate use | N (%) | N (%) | OR (95% CI) a | OR (95% CI) b |
Never use | 2808 (95.6) | 2788 (93.7) | 1.00 (Referent) | 1.00 (Referent) |
Ever use | 128 (4.4) | 187 (6.2) | 0.70 (0.56–0.89) | 0.70 (0.54–0.92) |
Former | 22 (0.7) | 26 (0.9) | 0.85 (0.48–1.51) | 0.91 (0.50–1.64) |
Current | 106 (3.6) | 161 (5.4) | 0.68 (0.53–0.88) | 0.67 (0.51–0.89) |
Duration of use (months) | ||||
3–12 | 58 (2.0) | 76 (2.5) | 0.78 (0.55–1.11) | 0.78 (0.54–1.12) |
13–24 | 26 (0.9) | 37 (1.2) | 0.72 (0.44–1.20) | 0.69 (0.41–1.17) |
⩾25 | 44 (1.5) | 74 (2.5) | 0.61 (0.42–0.90) | 0.63 (0.42–0.95) |
P-trend | 0.01 | 0.01 | ||
