Table 2 Predictors for chemotherapy response (complete and partial remission) using multivariate regression modeling

From: Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic–pharmacodynamic analysis from the IELSG no. 20 trial

Covariate

OR

95% CI

P -value

Patient gender

   

 Male

Ref

  

 Female

0.48

0.08–2.92

0.42

IELSG risk score

   

 0–1

Ref

  

 2–3

0.05

0.005–0.44

0.007

 4–5

0.03

0.002–0.48

0.01

Treatment group

   

 HD-MTX

Ref

  

 HD-MTX/HD-AraC

9.33

1.33–65.53

0.02

AUCHD-MTX (tertiles, μmol l−1 h−1)

 <830

Ref

  

 830–980

5.21

0.73–37.3

0.10

 >980

121.9

7.80–190.1

0.001

  1. Abbreviations: OR=odds ratio; CI=confidence interval; IELSG=International Extranodal Lymphoma Study Group; HD-MTX=high-dose methotrexate; HD-AraC=high-dose cytarabine; AUC=area under the curve; Ref=reference.
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