Figure 2
Effect of Ki26894 on the wound healing ability of cancer cells. (A) Representative pictures from three experiments are shown. The number of OCUM-2MLN cells that migrated over the wound line (dotted line) was increased by TGF-β1 treatment when compared with that of control. The migrating cells displayed spindle shapes characteristic of epithelial-to-mesenchymal transition (EMT). Ki26894 (10 μ M) downregulated the ability of OCUM-2MLN cells to migrate over a wound line. (B) TGF-β1 significantly stimulated the migration of scirrhous gastric cancer cells, but not of non-scirrhous gastric cancer cells. Ki26894 (10 μ M) significantly inhibited the migration of scirrhous gastric cancer cells.
