Table 3 Cox univariate analysis for metastasis-free survival

From: High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer

 

All patients ( n =265)

pN0 patients ( n =126)

pN+ patients ( n =139)

Characteristics

HR

CI

P- value

HR

CI

P- value

HR

CI

P- value

Age (years)

         

 <48

3.22

1.50–6.93

 

6.29

0.73–54.16

 

2.42

1.06–5.54

 

 48–53

1.30

0.55–3.09

 

2.18

0.20–24.09

 

1.06

0.42–2.69

 

 54–64

0.67

0.26–1.69

 

1.76

0.16–19.64

 

0.42

0.15–1.15

 

 >64

1.00

 

<0.001

1.00

 

0.202

1.00

 

<0.001

Menopausal status

 Pre

1.65

0.97–2.82

 

3.60

0.93–13.97

 

1.40

0.77–2.52

 

 Post

1.00

 

0.066

1.00

 

0.064

1.00

 

0.271

Surgical tumour size

 pT1

1.00

  

1.00

  

1.00

  

 ⩾pT2

3.64

1.83–7.25

0.001

1.80

0.50–6.44

0.365

3.57

1.50–8.45

0.004

Histological type

 Lobular

1.00

  

1.00

  

1.00

  

 Ductal

0.95

0.47–1.95

0.895

1.99

0.25–15.76

0.516

0.81

0.38–1.75

0.592

Lymph node status

 pN0

1.00

        

 pN+

3.67

1.85–7.30

<0.001

      

Histological grade a

 1

1.00

  

1.00

     

 2

6.06

0.82–44.93

 

0.80

0.09–7.21

    

 3

10.90

1.46–81.46

0.004

1.71

0.19–15.44

0.494

  

NAb

ER and PgR status

 ER and PgR positive

1.00

 

0.001

1.00

 

0.261

1.00

 

<0.001

 ER and/or PgR negative

2.47

1.44–4.23

 

0.31

0.04–2.42

 

3.43

1.89–6.23

 

Gabarapl1 status

 Log (1/gabarapl1)c

4.96

2.43–10.12

<0.001

1.32

0.20–8.92

0.777

14.96

4.80–46.60

<0.001

  1. Abbreviations: HR=hazard ratio; CI=confidence interval; ER= oestrogen receptor; PgR=progesterone receptor.
  2. P-values correspond to Cox regression model.
  3. aHistological grade defined only in ductal carcinoma.
  4. bNo events in histological grade 1 tumour subset.
  5. cHR for an increase of one log (1/gabarapl1).
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