Table 1 Type of event, by treatment

Event	RT alone ( N =285)		CMT ( N =292)
First event: relapse or death
Locoregional relapse^a	155		94
Locoregional relapse and distant relapse^a	7		7
Distant relapse	21		29
Death	56		83
Any event	239		213
Cause of death
Anal cancer	125		93
New cancer	18^b		34^c
Treatment related	5		6
Other causes	50		64
Cardiac		18		20
Cerebrovascular accident		5		6
Other vascular		3		3
Infection		15		17
Pulmonary		5		9
Other		4		9
Unknown	7		3
Total	205		200

Abbreviations: CMT=combined modality therapy; RT=radiotherapy.
^aWithin 6 weeks following the end of initial treatment, there were two RT-alone patients and seven CMT patients who died, and nine RT-alone patients and ten CMT patients who had a relapse.
^bLung (7), unknown primary (4), ureter (1), oesophagus (1), liver (1), laryngeal (1), gastric (1), large bowel (1), unknown (1).
^cLung (17), leukaemia (3), breast (2), rectal (1), prostate (1), bladder (1), cerebral glioma (1), neuroendocrine (1), colon (1), myelodysplasia (1), ovary (1), oesophagus (1), larynx (1), abdomen (1), unknown primary (1).

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