Table a1 Summary results on efficacy

From: Chemoradiation for the treatment of epidermoid anal cancer: 13-year follow-up of the first randomised UKCCCR Anal Cancer Trial (ACT I)

Event

RT alone

CMT

Locoregional relapse rate (%) at

 3 years

53.4

29.7

 5 years

57.1

32.3

 10 years

59.1

33.8

 12 years

59.1

33.8

Relapse-free survival rate (%) at

 3 years

38.4

51.1

 5 years

33.7

46.6

 10 years

23.5

36.2

 12 years

17.7

29.7

Colostomy-free survival rate (%) at

 3 years

40.5

50.4

 5 years

36.8

46.9

 10 years

25.6

35.6

 12 years

20.1

29.6

Overall survival rate (%) at

 3 years

60.0

64.6

 5 years

53.0

58.1

 10 years

35.8

41.5

 12 years

27.5

33.1

Anal cancer death rate (%) at

 3 years

35.9

25.9

 5 years

41.8

30.5

 10 years

47.7

35.3

 12 years

48.7

36.2

  1. Abbreviations: CMT=combined modality therapy; RT=radiotherapy.