Table a2 Type of event, by time to event and treatment

From: Chemoradiation for the treatment of epidermoid anal cancer: 13-year follow-up of the first randomised UKCCCR Anal Cancer Trial (ACT I)

 

0–1.9 years

2.0–4.9 years

5.0–9.9 years

10+ years

Event

RT alone ( N =285)

 

CMT ( N =292)

 

RT alone

 

CMT

 

RT alone

 

CMT

 

RT alone

 

CMT

 

First event: relapse or death

 Locoregional relapse

136

 

79

 

14

 

9

 

4

 

5

 

1

 

1

 

 Distant relapse

16

 

19

 

4

 

5

 

1

 

3

 

0

 

2

 

 Locoregional relapse and distant relapse

6

 

6

 

1

 

1

 

0

 

0

 

0

 

0

 

 Death

5

 

11

 

6

 

17

 

20

 

24

 

25

 

31

 

 Any event

163

 

115

 

25

 

32

 

25

 

32

 

26

 

34

 

Cause of death

 Anal cancer

68

 

47

 

44

 

30

 

12

 

13

 

1

 

3

 

 New cancer

0

 

3

 

2

 

5

 

9

 

9

 

7

 

17

 

 Treatment related

3

 

5

 

0

 

1

 

1

 

0

 

1

 

0

 

 Other causes

7

 

14

 

4

 

14

 

17

 

15

 

22

 

21

 

Cardiac

 

1

 

3

 

2

 

5

 

7

 

5

 

8

 

7

Cerebrovascular accident

 

2

 

3

 

0

 

2

 

1

 

0

 

2

 

1

Other vascular

 

2

 

2

 

1

 

0

 

0

 

1

 

0

 

0

Infection

 

0

 

2

 

1

 

1

 

5

 

6

 

9

 

8

Pulmonary

 

0

 

1

 

0

 

3

 

3

 

2

 

2

 

3

Other

 

2

 

3

 

0

 

3

 

1

 

1

 

1

 

2

 Unknown

3

 

0

 

0

 

1

 

2

 

0

 

2

 

2

 

Total

81

 

69

 

50

 

51

 

41

 

37

 

33

 

43

 
  1. Abbreviations: CMT=combined modality therapy; RT=radiotherapy.
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