Table 2 Numbers of cases (Obs), standardised incidence ratio (SIR) and absolute excess risk (AER) per 100 000 person-years of selected second primary cancers after lung cancer by sex and histology

From: Risks of second primary cancer among patients with major histological types of lung cancers in both men and women

 

Squamous cell carcinoma

Small cell carcinoma

Adenocarcinoma excluding bronchioalveolar

Cancer sites (ICD 9th revision)

Obs

SIR

95% CI

AER

Obs

SIR

95% CI

AER

Obs

SIR

95% CI

AER

Women

PY=34 344

PY=16 763

PY=48 929

All but non-melanoma skin

377

1.28

(1.16–1.42)

242.55

149

1.16

(0.98–1.36)

119.65

555

1.49

(1.37–1.62)

374.30

Smoking-related cancers

142

2.31

(1.94–2.72)

234.27

58

2.28

(1.73–2.95)

194.47

164

2.24

(1.91–2.61)

185.80

 Head and neck

31

5.69

(3.87–8.08)

74.41

9

3.49

(1.59–6.63)

38.31

13

1.85

(0.99–3.17)

12.23

 Oesophagus (150)

14

3.31

(1.81–5.56)

28.45

6

3.30

(1.21–7.18)

24.95

7

1.72

(0.69–3.55)

6.01

 Bladder and kidney

40

2.31

(1.65–3.14)

65.95

18

2.45

(1.45–3.88)

63.59

69

3.32

(2.58–4.21)

98.59

 Leukaemias (204–208)

9

1.28

(0.58–2.42)

5.73

9

3.06

(1.40–5.82)

36.14

22

2.50

(1.57–3.79)

27.00

 Other smoking-related cancers

37

1.94

(1.36–2.67)

52.14

10

1.45

(0.70–2.67)

18.58

41

1.93

(1.38–2.62)

40.34

Colorectal (153, 154)

41

0.84

(0.60–1.14)

−22.74

14

0.67

(0.36–1.12)

−41.14

74

1.26

(0.99–1.58)

31.21

 Colon (153)

30

0.90

(0.61–1.29)

−9.71

9

0.63

(0.29–1.19)

−31.53

56

1.43

(1.08–1.86)

34.42

 Rectum (154)

11

0.70

(0.35–1.24)

−13.73

5

0.75

(0.24–1.74)

−9.94

18

0.93

(0.55–1.46)

−2.77

Non-smoking-related cancer

194

1.06

(0.91–1.22)

31.03

77

0.93

(0.74–1.16)

−33.66

317

1.32

(1.18–1.47)

157.14

 Female breast (174)

87

1.09

(0.88–1.35)

20.92

29

0.77

(0.52–1.11)

−51.68

135

1.25

(1.05–1.48)

55.12

 Cervix uteri (180)

11

1.31

(0.65–2.35)

7.58

6

1.56

(0.57–3.41)

12.85

12

1.07

(0.55–1.87)

1.63

 Corpus uteri (182)

8

0.43

(0.19–0.85)

−30.88

3

0.36

(0.07–1.05)

−31.82

19

0.76

(0.46–1.18)

−12.52

 Ovary (183)

23

1.47

(0.93–2.21)

21.41

9

1.28

(0.59–2.43)

11.74

28

1.37

(0.91–1.98)

15.52

 Thyroid gland (193)

6

2.48

(0.91–5.40)

10.43

3

2.64

(0.54–7.71)

11.12

18

4.87

(2.88–7.69)

29.23

 Other non-smoking-related cancers

59

1.01

(0.76–1.30)

1.57

27

1.10

(0.72–1.60)

14.12

105

1.47

(1.20–1.77)

68.16

Men

PY=212 428

PY=34 293

PY=64 945

All but non-melanoma skin

2882

1.21

(1.16–1.25)

231.99

408

1.16

(1.05–1.27)

160.26

1012

1.47

(1.38–1.56)

498.00

Smoking-related cancers

1454

1.58

(1.50–1.66)

250.63

186

1.39

(1.20–1.60)

151.44

428

1.73

(1.57–1.90)

277.11

 Head and neck

340

2.53

(2.27–2.81)

96.76

33

1.50

(1.04–2.11)

32.26

77

2.01

(1.59–2.51)

59.57

 Oesophagus (150)

93

1.78

(1.44–2.18)

19.18

12

1.46

(0.75–2.55)

11.03

27

1.91

(1.26–3.09)

19.76

 Bladder and kidney

565

1.87

(1.72–2.03)

123.83

70

1.62

(1.26–2.04)

77.98

159

1.90

(1.62–2.22)

116.16

 Leukaemias (204–208)

74

0.98

(0.77–1.23)

−0.71

14

1.29

(0.71–2.17)

9.18

33

1.58

(1.09–2.37)

18.62

 Other smoking-related cancers

382

1.07

(0.96–1.18)

11.56

57

1.14

(0.87–1.48)

21.01

132

1.45

(1.21–1.72)

62.99

Colorectal (153, 154)

395

1.01

(0.92–1.12)

1.84

46

0.79

(0.58–1.05)

−35.66

129

1.15

(0.96–1.38)

25.91

 Colon (153)

223

1.00

(0.87–1.14)

0.00

29

0.85

(0.57–1.22)

−14.92

81

1.24

(0.98–1.57)

24.14

 Rectum (154)

172

1.04

(0.89–1.21)

3.11

17

0.70

(0.41–1.13)

−21.25

48

1.02

(0.76–1.36)

1.45

Non-smoking-related cancer

1033

0.96

(0.90–1.02)

−20.48

176

1.09

(1.21–1.58)

44.48

455

1.39

(1.26–1.52)

195.41

 Prostate (185)

694

1.06

(0.98–1.14)

18.49

111

1.19

(0.98–1.43)

51.68

312

1.56

(1.39–1.79)

172.37

 Testis (186)

5

1.10

(0.36–2.56)

0.21

1

1.26

(0.03–6.99)

0.60

5

3.14

(1.01–9.55)

5.25

 Thyroid gland (193)

10

1.14

(0.55–2.10)

0.58

4

3.04

(0.83–7.79)

7.83

9

3.43

(1.57–8.62)

9.82

 Other non-smoking-related cancers

324

0.79

(0.71–0.88)

−39.77

60

0.92

(0.70–1.18)

−15.63

129

1.04

(0.87–1.24)

7.98

  1. Abbreviations: CI=confidence interval; ICD=International Classification of Disease; Obs=observed number; PY=person-years.
  2. Smoking-related cancers included: head and neck (ICD-9: lip: 140, tongue: 141, mouth: 143–145, oropharynx: 146, hypopharynx: 148, pharynx unspecified: 149, and larynx: 161), salivary gland (142), nasopharynx (147), oesophagus (150), nose and nasal cavity (160), stomach (151), liver (155), and pancreas (157), bladder and kidney (188 189), leukaemia (204–208).
  3. AER is expressed as per 100 000.
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