Table 3 Dose of non-steroidal anti-inflammatory drugs (NSAID) use and risk of pancreatic cancer

From: Non-steroidal anti-inflammatory drugs and pancreatic cancer risk: a nested case–control study

Period of NSAID use

5 years before index date, excluding the year before index date

Until 1 year before index date

NSAID dose (DDDs)

Cases ( n)

Controls ( n)

OR (95% CI)

Adjusted OR (95% CI) a

NSAID dose (DDDs)

Cases ( n)

Controls ( n)

OR (95% CI)

Adjusted OR (95% CI) a

No use: 0

534

3776

1.0

1.0

No use: 0

345

2565

1.0

1.0

Category 1: 0–9.20

156

1058

1.04 (0.86–1.26)

0.98 (0.80–1.20)

Category 1: 0–31.5

192

1354

1.06 (0.88–1.28)

1.01 (0.83–1.23)

Category 2: 9.25–26.50:

145

1059

0.97 (0.80- 1.18)

0.91 (0.74–1.11)

Category 2: 31.55–90.5

217

1357

1.20 (1.00–1.43)

1.11 (0.91–1.34)

Category 3: 26.55–100.50:

160

1020

1.11 (0.92- 1.35)

1.04 (0.85–1.27)

Category 3: 90.55–298

198

1333

1.11 (0.92–1.35)

1.03 (0.84–1.26)

Category 4: >100.50

146

1041

0.99 (0.81–1.21)

0.93 (0.77–1.15)

Category 4: >298

189

1345

1.05 (0.87–1.28)

0.96 (0.78–1.18)

  1. Abbreviation: DDD=defined daily dose.
  2. a Adjusted for smoking status, body mass index, alcohol use, history of chronic pancreatitis, history of rheumatoid arthritis, use of other drugs (proton pump inhibitors, H2 antagonists, steroids, hormone replacement therapy, disease modifying anti-rheumatic drugs), diabetes and prior cancer.