Table 4 Duration of non-steroidal anti-inflammatory drugs (NSAID) use and risk of pancreatic cancer

From: Non-steroidal anti-inflammatory drugs and pancreatic cancer risk: a nested case–control study

Period of NSAID use

5 years before index date, excluding the year before index date

Until 1 year before index date

NSAID duration (days)

Cases ( n)

Controls ( n)

OR (95% CI)

Adjusted OR (95% CI) a

NSAID duration (days)

Cases ( n)

Controls ( n)

OR (95% CI)

Adjusted OR (95% CI) a

No use

534

3776

1.0

1.0

No use

345

2565

1.0

1.0

Category 1: 0–33.5

155

1078

1.02 (0.84–1.23)

0.97 (0.79–1.18)

Category 1: 0–40.5

204

1377

1.10 (0.92–1.34)

1.06 (0.87–1.28)

Category 2: 33.6–156.5

152

1013

1.06 (0.88–1.29)

1.01 (0.83–1.24)

Category 2: 40.6–156.5

204

1320

1.16 (0.96–1.40)

1.09 (0.90–1.33)

Category 3: 156.6–773

171

1044

1.15 (0.96–1.39)

1.08 (0.89–1.32)

Category 3: 156.6–834

214

1346

1.18 (0.98–1.43)

1.08 (0.88–1.31)

Category 4 >773

129

1043

0.87 (0.70–1.07)

0.78 (0.62–0.97)

Category 4: >834

174

1346

0.96 (0.79–1.18)

0.86 (0.69–1.06)

  1. a Adjusted for smoking status, body mass index, alcohol use, history of chronic pancreatitis, use of other drugs (proton pump inhibitors, H2 antagonists, steroids ), diabetes and prior cancer.