Figure 5 | British Journal of Cancer

Figure 5

From: EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in HER2/ER-positive breast cancer cells but functions synergistically with endocrine therapy

Figure 5

AEE788 in combination with letrozole is more effective at reducing tumour volume compared with either treatment alone. ZR75.1 A3 xenografts were grown in the presence of androstenedione. Once tumours reached the desired size, animals were randomised to receive vehicle, tamoxifen, letrozole, AEE788 or a combination of agents. Tumour volume was measured at the intervals indicated and expressed as percentage change in tumour volume relative to day 0. Bars represent ±s.e.m.

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