Table 4 Worst non-haematological drug-related toxicity per patients (all cycles)
Treatment arm | Number of patients | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Carboplatin arm | Paclitaxel arm | Triplet arm | |||||||
CTCAE grade Toxicity | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
Fatigue | 4 | 5 | 3 | 5 | 7 | — | 3 | 5 | — |
Pain | 6 | 4 | 2 | 2 | 8 | 2 | 1 | 5 | 0 |
Sensory neuropathy | 6 | — | 1 | 8 | 1 | 1 | 5 | 3 | — |
Alopecia | — | — | — | 2 | 12 | — | 1 | 7 | — |
Nausea | 4 | 5 | — | 4 | 2 | — | 3 | 4 | — |
Pain – headache | 1 | 5 | 1 | 3 | 1 | — | 1 | 4 | — |
QTc prolongation | 3 | — | — | 7 | 2 | — | 2 | 1 | — |
Vomiting | 3 | 2 | 1 | 3 | 3 | — | — | 2 | — |
Hypertension | 3 | 2 | — | 1 | 2 | — | 3 | — | 1 |
Constipation | — | 4 | — | 1 | 4 | — | — | 2 | — |
Diarrhoea | 2 | 1 | 3 | 1 | 1 | — | 2 | 3 | |
Pyrexia | 3 | — | — | 5 | 2 | — | 1 | — | — |
Flushing | 3 | 1 | — | 1 | — | — | 2 | 1 | — |
Hypotension | — | 1 | — | 1 | 3 | — | 1 | 2 | — |
Itching | 3 | — | — | 1 | — | — | 4 | — | — |
Anorexia | 1 | 1 | — | — | — | — | 4 | 1 | — |
Infection | — | 1 | — | — | 1 | 2 | 2 | 1 | — |
Myalgia | 1 | — | — | 3 | — | — | 2 | 1 | — |
Neurological: muzzy head | 2 | — | — | 2 | — | — | 1 | — | — |
Oedema | 2 | 1 | — | 1 | 1 | — | — | — | — |
Perianal itching | 3 | — | — | 1 | — | — | 1 | — | — |
Rash | — | 1 | — | 1 | 1 | 2 | — | — | — |
Stomatitis | 1 | — | — | 1 | 1 | — | 2 | — | — |
Tachycardia | 1 | — | — | 2 | — | — | 2 | — | — |
Agitation | 2 | — | 1 | 1 | — | — | — | — | — |
Cough | — | 1 | — | 1 | — | 1 | — | — | — |
Motor neuropathy | — | 1 | 1 | — | — | 1 | — | — | — |
Allergy | — | — | 1a | — | — | 1 | 1 | — | — |
Ataxia | — | — | — | — | — | — | — | 1 | 1 |
Dysphasia | — | 1 | 1 | — | — | — | — | — | — |
Dehydration | — | — | — | — | — | 1 | — | — | — |
Incontinence | — | — | 1 | — | — | — | — | — | — |
Sepsis | — | — | 1 | — | — | — | — | — | — |
