Table 4 Pathways regulated by cachexia in adipose tissue according to GSEA

From: Adipose tissue pathways involved in weight loss of cancer cachexia

Pathways

No. of genes

Nominal P

FDR q -value

Enriched in cachexia

 ELECTRON_TRANSPORT_CHAIN

98

0.008

0.19

 STATIN_PATHWAY_PHARMGKB

18

0.002

0.15

 FATTY_ACID_DEGRADATION

23

0.004

0.17

 MOOTHA_VOXPHOS

77

0.025

0.14

 OXIDATIVE_PHOSPHORYLATION

59

0.041

0.17

 FATTY_ACID_SYNTHESIS

16

0.018

0.16

 KREBS_TCA_CYCLE

31

0.012

0.16

 ADIPOCYTE_PPARG_UP

16

0.021

0.14

 UBIQUINONE_BIOSYNTHESIS

15

0.002

0.14

 HUMAN_MITODB_6_2002

379

0.029

0.13

 NADLER_OBESITY_DN

36

0.028

0.12

 ALANINE_AND_ASPARTATE_ METABOLISM

21

0.022

0.12

 HYPOPHYSECTOMY_RAT_UP

34

0.03

0.13

 TNFALPHA_TGZ_ADIP_DN

28

0.046

0.15

 CITRATE_CYCLE_TCA_CYCLE

19

0.022

0.15

 TCA

15

0.004

0.14

 MITOCHONDRIA

387

0.051

0.14

 FATTY_ACID_METABOLISM

79

0.05

0.17

Enriched in controls

 PASSERINI_EM

34

0

0.19

 SCHRAETS_MLL_UP

33

0

0.17

  1. Abbreviations: FDR=false discovery rate; GSEA=Gene Set Enrichment Analysis.
  2. Shown are pathways with an FDR q-value <0.20.
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