Figure 3 | British Journal of Cancer

Figure 3

From: Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer

Figure 3

FISH analysis confirms that samples processed by the CPK method have a low percentage of contaminating normal cells. Representative FISH images of cells processed by CPK method, (A) lymphocyte with two copies of CEP7 (green), EGFR (red), and MET (blue), (B) CTC with amplified EGFR and MET. (C) Percentage of total cells captured by the CPK method from patients with NSCLC with ⩾4 copies of EGFR, CEP7, and MET per nucleus. (D) Percentage of total cells captured by the CPK method from patients with clinically defined HER2-positive (patient number 1–24) or HER2-negative (patient number 25–30) breast cancer, with the indicated copies of HER2 per nucleus.

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