Table 4 Association with childcare attendance and CNS tumours overall, astrocytoma, and embryonal CNS tumour

From: Infectious exposure in the first years of life and risk of central nervous system tumours in children: analysis of birth order, childcare attendance and seasonality of birth

 

All CNS tumours a

Astrocytoma

Embryonal CNS tumour

 

No. of cases

No. of controls

OR b

95% CI

No. of cases

No. of controls

OR b

95% CI

No. of cases

No. of controls

OR b

95% CI

Children in analysis

348

3380

  

128

1258

  

49

488

  

Attendance to childcare

 Ever

125

1090

1.29

(0.90–1.86)

46

390

1.19

(0.67–2.13)

23

194

1.47

(0.57–3.77)

 Never

45

511

1.00

Ref.

19

188

1.00

Ref.

6

73

1.00

Ref.

 Incomplete registrationc

178

1779

1.12

(0.78–1.61)

63

680

0.84

(0.47–1.51)

20

221

1.05

(0.40–2.80)

Age at enrolment in childcare

128

1258

  

49

488

  

 Never

45

511

1.00

Ref.

19

188

1.00

Ref.

6

73

1.00

Ref.

 <6 months

21

185

1.29

(0.75–2.24)

6

57

1.06

(0.41–2.79)

8

30

3.39

(1.08–10.71)

 6–11 months

53

491

1.20

(0.79–1.85)

21

174

1.23

(0.62–2.42)

9

86

1.32

(0.44–3.92)

 12–17 months

34

288

1.32

(0.82–2.13)

13

114

1.15

(0.53–2.46)

6

53

1.36

(0.42–4.41)

 18–23 months

17

126

1.55

(0.86–2.81)

6

45

1.34

(0.51–3.54)

0

25

 d

 

 Incomplete registrationc

178

1779

1.12

(0.78–1.61)

63

680

0.84

(0.47–1.51)

20

221

1.04

(0.39–2.76)

Time enroled in childcare

128

1258

  

49

488

  

 Never

45

511

1.00

Ref.

19

188

1.00

Ref.

6

73

1.00

Ref.

 <6 months

20

140

1.63

(0.93–2.85)

6

48

1.25

(0.48–3.29)

0

29

 d

 

 6–11 months

34

301

1.27

(0.79–2.04)

13

123

1.05

(0.49–2.25)

7

54

1.55

(0.49–4.84)

 12–23 months

71

649

1.23

(0.82–1.83)

27

219

1.26

(0.66–2.39)

16

111

1.84

(0.68–4.97)

 Incomplete registrationc

178

1779

1.12

(0.78–1.61)

63

680

0.84

(0.47–1.51)

20

221

1.04

(0.39–2.76)

Type of daycare e

 Never

45

511

1.00

Ref.

19

188

1.00

Ref.

6

73

1.00

ref

 Crèche only

26

168

1.75

(1.04–2.93)

8

61

1.36

(0.56–3.30)

5

28

2.25

(0.63–8.05)

 Daycare home only

65

138

1.15

(0.77–1.73)

25

229

1.11

(0.59–2.12)

11

114

1.18

(0.41–3.33)

 Age-integrated only

22

174

1.39

(0.81–2.40)

7

65

1.07

(0.43–2.67)

4

29

1.71

(0.45–6.51)

 Enroled in various types

12

110

1.26

(0.78–1.61)

6

35

1.82

(0.64–5.15)

3

23

1.65

(0.36–7.48)

 Incomplete registrationc

178

1779

1.12

(0.78–1.61)

63

680

0.84

(0.47–1.51)

20

221

1.04

(0.39–2.77)

  1. Abbrevations: 95%CI=95% confidence interval; CN=central nervous system; No.=number; OR=odds ratio.
  2. aTumours classified according to the international classification of childhood cancer version 3, main group III are included.
  3. bAdjusted for matching variables, namely, sex, month, and year of birth.
  4. cIncludes children for whom the complete history of childcare during the first 2 years was not known, for example, moving to an uncovered municipality, migration, or death.
  5. dNo cases with embryonal CNS tumour were in this category.
  6. eDaycare homes enrol up to five children aged 0–3 years, crèches enrol an average of 40 children aged 0–3 years, and age-integrated facilities enrol a mean of 73 children aged 0–6 years.
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