Table a2 Cases of progression to HGD or adenocarcinoma

From: Image cytometry accurately detects DNA ploidy abnormalities and predicts late relapse to high-grade dysplasia and adenocarcinoma in Barrett's oesophagus following photodynamic therapy

Study ID

Length BE (cm)

DNA ploidy status at baseline

No. of levels DNA ploidy

No. of levels of HGD

Peak DI

Mean CV

Mean n in G1 peak

Peak 5c

DNA ploidy status at 4 months

No. of levels DNA ploidy

Histology

Peak DI

Mean CV

Mean n in G1 peak

Peak 5c

DNA ploidy status at 12 months

No. of levels DNA ploidy

Histology

Peak DI

Mean CV

Mean n in G1 peak

Peak 5c

 1

6

Aneuploid

1

1

1.51

7.2

744

2.13

Hypodiploid

1

IM

0.73

8

777

0

Diploid

0

LGD

1.01

6.8

852

0

 2

6

Aneuploid and tetraploid

1

1

1.32/2.02

10.9

1018

0.54

Aneuploid

2

Indefinite

1.52

9.2

557

0.74

Aneuploid

1

IM

1.26

10.5

985

0.17

 3

7

Aneuploid, tetraploid

2

1

1.76/1.97

7.7

863

0.99

Aneuploid and tetraploid

2

IM

1.29/1.99

10.7

363

0.23

Aneuploid and tetraploid

1

LGD

0.5/2.05

6.8

576

0

 4

3

Aneuploid

1

1

1.89

9.6

907

1.20

Aneuploid

1

Glandular mucosa

1.65

10.2

807

0.41

Aneuploid

1

IM

1.88

9.5

510

0.4

 5

11

Aneuploid and tetraploid

3

2

1.48/1.97

6.7

503

1.07

Aneuploid

2

Indefinite

1.75

6.0

681

0.29

Not reportable

 

IM

    

 6

3

Aneuploid

1

1

1.89

15.1

986

0.76

Aneuploid

2

IM

1.63

9.0

525

0.14

Aneuploid

1

Indefinite

1.38

5.0

923

0.15

 7

5

Aneuploid

2

1

1.56

9.3

725

0.37

Diploid

0

Indefinite

1.00

4.4

1103

0

Hypodiploid and tetraploid

1

IM

0.50/1.97

10.1

392

0

 8

4

Aneuploid

1

1

1.83

10.4

648

0

Diploid

0

Glandular mucosa

1.01

5.9

916

0

Aneuploid

3

Glandular mucosa

1.85

11.6

224

1.50

 9

13

Aneuploid and tetraploid

6

3

1.74/2.05

9.43

708

1.79

Aneuploid

1

IM

1.79

6.3

680

0.11

Aneuploid

1

IM

1.87

7.4

773

0.26

10

3

Aneuploid

1

1

1.31

8.6

626

0.78

Aneuploid

3

Mixed sqaumo-glandular

1.83

6.4

745

0.21

Diploid

0

Mixed squamo-glandular

1.00

4.6

1051

0

11

5

Diploid

0

1

0.99

5.7

888

0

Diploid

0

Glandular mucosa

1.0

4.2

903

0

Aneuploid

1

Glandular mucosa

1.40

13

399

0.83

12

4

Diploid

0

1

1.01

6.7

1194

0

Diploid

0

IM

1.02

6.3

1064

0

Diploid

0

IM

1.03

11.1

809

0

13

2

Diploid

0

1

1.03

9.4

1274

0

Diploid

0

Indefinite

0.99

7.1

1059

0

Diploid

0

Indefinite

1.01

8.5

945

0

  1. Abbreviations: BE=Barrett's oesophagus; CV=coefficient of variance; DI=DNA index; HGD=high-grade dysplasia; ICDA=image cytometric DNA analysis; LGD=low-grade dysplasia.
  2. Corresponding histology and raw ICDA data at three time points are shown.
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