Table 2 BRAF mutation and MSI status and correlations with PFS and OS

From: BRAF mutations, microsatellite instability status and cyclin D1 expression predict metastatic colorectal patients’ outcome

 

MSI-H, n =22 (15%)

MSS, n =122 (85%)

Total ( n =144)

N (%)

Median (months)

N (%)

Median (months)

P -value

Progression-free survival

 BRAF mutant, n=12 (8%)

10 (45)

3.1

2 (1.6)

1.6

0.003&

 BRAF wt, n=132 (92%)

12 (55)

11.4

120 (98.4)

9.7

0.2@

 P-value

 

0.008*

 

<0.001#

 

Median overall survival

 BRAF mutant, n=12 (8%)

10 (45)

14.5

2 (1.6)

2.6

0.05&

 BRAF wt, n=132 (92%)

12 (55)

35.5

120 (98.4)

30.2

0.4@

 P-value

 

0.004*

 

<0.001#

 
  1. Abbreviation: MSI=microsatellite instability.
  2. *P-value: MSI-H BRAF mutant vs MSI-H BRAF wt.
  3. #P-value: MSS BRAF mutant vs MSS BRAF wt.
  4. &P-value: MSI-H BRAF mutant vs MSS BRAF mutant.
  5. @P-value: MSI-H BRAF wt vs MSS BRAF wt.
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