Figure 1
From: Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells
Dichloroacetate (20 mM) did not significantly reduce growth of cultures of the non-cancerous 293 and HB2 cells but caused a significant reduction in growth of cultures of all the colorectal cancer cells (*P⩽0.009). Cells were treated with various doses of DCA or vehicle control in normoxia (A and C) or hypoxia (B and D), and the relative number of viable cells was assessed at 24 h (A and B) and 48 h (C and D) using MTT assay. Data are expressed as percentage of control (0 mM dose) (* – significant difference relative to control – white bar (0 mM)).
