Table 4 Cox regression analysis on IHC and clinical factors, both univariate and multivariate
Cox regression | N (%) | Hazard ratio (HR) for LRR (95% CI; P -value) |
|---|---|---|
Univariate | ||
EGFR | ||
Low | 123 (89) | 1 |
High | 17 (11) | 0.5 (0.1–2.0; P=0.32) |
pEGFR | ||
Low | 84 (60) | 1 |
High | 56 (40) | 1.2 (0.6–2.6; P=0.58) |
PI3K | ||
Low | 87 (62) | 1 |
High | 53 (38) | 0.6 (0.3–1.4; P=0.25) |
PTEN | ||
Low | 97 (69) | 1 |
High | 43 (31) | 2.4 (1.2–5.0; P=0.019)* |
pAKT | ||
Low | 105 (75) | 1 |
High | 35 (25) | 2.2 (1.0–4.6; P=0.043)* |
pERK | ||
Negative | 118 (84) | 1 |
Positive | 22 (16) | 1.2 (0.5–3.0; P=0.65) |
HER2 | ||
Low | 129 (92) | 1 |
High | 11 (8) | 1 (0.2–4.2; P=0.99) |
Lymph nodes | ||
Negative | 50 (36) | 1 |
Positive | 90 (64) | 5.7 (2.0–16.3; P=0.001)* |
ENS | ||
No | 89 (64) | 1 |
Yes | 51 (36) | 5 (2.4–10.6; P<0.001)* |
Surgical margins | ||
Free | 43 (31) | 1 |
Not free | 97 (69) | 1.4 (0.6–3.2; P=0.37) |
Multivariate | ||
PTEN | ||
Low | 97 (69) | 1 |
High | 43 (31) | 2.2 (1.1–4.6; P=0.03)* |
Lymph nodes | ||
Negative (N0) | 50 (36) | 1 |
Positive (N+) | 90 (64) | 5.7 (1.2–27.4; P=0.03)* |
ENS | ||
No | 89 (64) | 1 |
Yes | 51 (36) | 2.7 (1.2–6.5; P=0.02)* |
