Table 2 Estimates of SIRs for familial risk of early and late onset nervous system tumours in offspring
From: Familial risks in nervous system tumours: joint Nordic study
Sweden, Norway, Denmark and Iceland | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SIR by concordant family history | SIR by family history of cancer in the nervous system | ||||||||||||||||||||||||
Parental proband | Sibling proband | Parent and sibling proband | Parental proband | Sibling proband | Parent and sibling proband | ||||||||||||||||||||
Subsite and age in cases | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | Cases | ||||||
Brain | |||||||||||||||||||||||||
0–19 years | 67 | 1.7 | 1.3 | 2.1 | 35 | 2.7 | 1.9 | 3.7 | — | — | 86 | 1.9 | 1.5 | 2.3 | 40 | 2.6 | 1.8 | 3.5 | 5 | 15.3 | 4.8 | 35.9 | 5751 | ||
20+ years | 286 | 1.7 | 1.5 | 1.9 | 166 | 1.9 | 1.6 | 2.2 | 17 | 10.8 | 6.3 | 17.3 | 314 | 1.6 | 1.4 | 1.8 | 19.5 | 1.9 | 1.6 | 2.2 | 20 | 9.5 | 5.8 | 14.7 | 20 991 |
All ages | 353 | 1.7 | 1.5 | 1.8 | 201 | 2.0 | 1.7 | 2.3 | 17 | 9.4 | 5.5 | 15.1 | 400 | 1.7 | 1.5 | 1.8 | 235 | 2.0 | 1.7 | 2.2 | 25 | 10.3 | 6.7 | 15.2 | 26 742 |
Spine | |||||||||||||||||||||||||
0–19 years | 3 | 14.0 | 2.6 | 41.4 | 2 | 22.7 | 2.1 | 83.7 | — | — | 14 | 3.6 | 2.0 | 6.1 | 4 | 3.0 | 0.8 | 7.6 | — | — | 440 | ||||
20+ years | 1 | 1.4 | 0.0 | 8.2 | 2 | 4.2 | 0.4 | 15.5 | — | — | 22 | 1.5 | 0.9 | 2.2 | 16 | 2.1 | 1.2 | 3.4 | 2 | 12.8 | 1.2 | 47.0 | 1590 | ||
All ages | 4 | 4.4 | 1.1 | 11.3 | 4 | 7.1 | 1.8 | 18.4 | — | — | 36 | 1.9 | 1.3 | 2.6 | 20 | 2.2 | 1.4 | 3.4 | 2 | 10.8 | 1.0 | 39.9 | 2030 | ||
Peripheral nerves a | |||||||||||||||||||||||||
0–19 years | 11 | 29.8 | 14.8 | 53.5 | 5 | 24.7 | 7.8 | 58.1 | — | — | 15 | 2.5 | 1.4 | 4.1 | 8 | 3.8 | 1.6 | 7.6 | 3 | 63.0 | 11.9 | 186.6 | 685 | ||
20+ years | 5 | 8.2 | 2.6 | 19.2 | 12 | 29.2 | 15.0 | 51.1 | 4 | 1816.7 | 472.5 | 4697.6 | 22 | 1.5 | 0.9 | 2.3 | 19 | 2.6 | 1.6 | 4.1 | 7 | 45.5 | 18.0 | 94.3 | 1037 |
All ages | 16 | 16.3 | 9.3 | 26.6 | 17 | 27.7 | 16.1 | 44.4 | 4 | 943.9 | 245.5 | 2440.6 | 37 | 1.8 | 1.3 | 2.5 | 27 | 2.9 | 1.9 | 4.2 | 10 | 49.7 | 23.6 | 91.7 | 1722 |
Nervous system | |||||||||||||||||||||||||
0–19 years | 118 | 2.1 | 1.8 | 2.6 | 54 | 2.9 | 2.2 | 3.8 | 8 | 20.4 | 8.7 | 40.5 | 6963 | ||||||||||||
20+ years | 375 | 1.6 | 1.4 | 1.7 | 240 | 1.9 | 1.6 | 2.1 | 29 | 11.1 | 7.4 | 16.0 | 24 374 | ||||||||||||
All ages | 493 | 1.7 | 1.5 | 1.8 | 294 | 2.0 | 1.8 | 2.2 | 37 | 12.3 | 8.7 | 17.0 | 31 337 | ||||||||||||
