Figure 4
From: In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosin
Tissue distribution of doxorubicin. Balb/c mice were injected with doxorubicin alone i.v. (10 mg kg–1) or with TBN (50 mg kg–1) i.p. 3 h before doxorubicin i.v. (10 mg kg–1). At various times after doxorubicin injection (30 min, 1, 5, 24 and 48 h) three to five mice were killed. Plasma and tissue samples from liver, kidneys and heart were collected and stored at −20°C until extraction and liquid chromatography analysis. The values are mean ± s.e.
