Table 1 Univariate analysis – recurrence of ipsilateral DCIS or invasive disease
Feature | Categories | No. cases | No. events | HR (95% CI) | χ 2 for trend P- value |
|---|---|---|---|---|---|
Cytonuclear grade (National Pathology Co-ordinating Group, 2005) | Low | 86 | 6 | 0.51 (0.22–1.15) | 14.58 |
Intermediate | 225 | 13 | 0.41 (0.23–0.72) | P=0.0007 | |
High | 913 | 135 | 1.00a | ||
Traditional/historical nomenclature | Small cell micropapillary | 17 | 3 | 1.32 (0.42–4.16) | 39.34 |
Small cell cribriform | 86 | 0 | 0 (0.00–0.20) | P<0.0001 | |
Small cell solid | 31 | 3 | 0.53 (0.17–1.68) | ||
Small cell mixed | 65 | 7 | 0.63 (0.29–1.37) | ||
Large cell mixed | 298 | 31 | 0.60 (0.40–0.90) | ||
Large cell cribriform | 130 | 10 | 0.41 (0.21–0.80) | ||
Large cell solid | 86 | 11 | 0.75 (0.40–1.40) | ||
Comedo | 483 | 88 | 1.00a | ||
Papillary | 28 | 1 | 0.20 (0.03–1.45) | ||
Van Nuys grade (Silverstein et al, 1995) | Non-high grade without necrosis | 99 | 5 | 0.39 (0.16–0.94) | 14.58 |
Non-high grade with necrosis | 212 | 14 | 0.45 (0.26–0.78) | P=0.0007 | |
High | 913 | 135 | 1.00a | ||
Nottingham grade (Poller et al, 1994) | DCIS without necrosis | 117 | 6 | 0.58 (0.25–1.35) | 19.38 |
Non-pure comedo | 624 | 88 | 1.00a | P=0.0001 | |
Comedo | 483 | 60 | 1.85 (1.33–2.57) | ||
Differentiation (Holland et al, 1994) | Well differentiated | 90 | 6 | 0.38 (0.22–0.66) | 18.09 |
Moderately differentiated | 248 | 14 | 0.47 (0.21–1.07) | P=0.0001 | |
Poorly differentiated | 886 | 134 | 1.00a | ||
Main architecture | Solid | 731 | 111 | 1.00a | 15.14 |
Cribriform | 372 | 27 | 0.47 (0.31–0.71) | P=0.002 | |
Micropapillary | 91 | 13 | 0.97 (0.54–1.71) | ||
Papillary | 30 | 3 | 0.50 (0.20–2.02) | ||
Necrosis | Confluent comedo necrosis present | 1107 | 147 | 1.00a | 4.07 |
Confluent comedo necrosis not present | 117 | 7 | 0.50 (0.23–1.06) | P=0.04 | |
Age | >50 yearsa | 1132 | 137 | 1.00a | 3.74 |
⩽50 years | 92 | 17 | 1.71 (1.03–2.82) | P=0.05 | |
Chronic inflammation associated with DCIS | Present | 924 | 135 | 1.00a | 12.78 |
Not present | 296 | 19 | 0.45 (0.27–0.73) | P<0.0001 | |
Histological calcification | Present | 1089 | 135 | 1.00a | 1.11 |
Not present | 129 | 19 | 1.31 (0.81–2.11) | NS | |
Tumour size | 0–0.9 cm | 368 | 27 | 0.55 (0.35–0.85) | 20.04 |
1.0–1.9 cm | 575 | 77 | 1.00a | P<0.0001 | |
>2.0 cm | 268 | 49 | 1.55 (1.08–2.22) | ||
Excision | Complete (1 mm or more from margin) | 846 | 91 | 1.00a | 7.77 |
Incomplete (DCIS<1 mm from margin) | 196 | 31 | 1.50 (1.00–2.26) | P=0.02 | |
Uncertain | 182 | 32 | 1.67 (1.12–2.50) |
