Table 2a New grading system – recurrence of ipsilateral DCIS or invasive carcinoma

From: A new pathological system for grading DCIS with improved prediction of local recurrence: results from the UKCCCR/ANZ DCIS trial

Feature

Category

No. cases

No. events

HR (95% CI)

χ 2 for trend, P- value

Recurrence of ipsilateral DCIS or invasive

     

Grading system, four tier

Low

86

6

0.42 (0.18–0.95)

22.11

 

Intermediate

225

13

0.33 (0.19–0.60)

P=0.0001

 

High

430

47

0.62 (0.43–0.88)

 
 

Very high

483

88

1.00a

 

New grade, three tier

Low/intermediate

311

19

0.36 (0.22–0.58)

21.91

 

High

430

47

0.62 (0.43–0.88)

P=0.0001

 

Very high

483

88

1.00a

 

Recurrence of ipsilateral DCIS

     

Grading system, four tier

Low

86

4

0.44 (0.15–1.20)

15.42

 

Intermediate

225

7

0.28 (0.12–0.62)

P=0.002

 

High

430

32

0.66 (0.43–1.02)

 
 

Very high

483

56

1.00

 

New grade, three tier

Low/intermediate

311

11

0.32 (0.16–0.61)

14.97

 

High

430

32

0.66 (0.43–1.02)

P=0.0006

 

Very high

483

56

1.00

 

Recurrence of ipsilateral invasive

     

Grading system, four tier

Low

86

2

0.41 (0.10–1.72)

6.67

 

Intermediate

225

6

0.46 (0.19–1.11)

P=0.08

 

High

430

14

0.53 (0.28–0.99)

 
 

Very high

483

32

1.00

 

New grade, three tier

Low/intermediate

311

8

0.45 (0.21–0.98)

6.65

 

High

430

14

0.53 (0.28–0.99)

P=0.04

 

Very high

483

32

1.00

 
  1. Abbreviations: CI=confidence interval; DCIS=ductal carcinoma in situ; HR=hazard ratio.
  2. aBaseline category. NB: There is one ipsilateral event for which it is unknown whether the recurrence was DCIS or invasive.