Table 3 Non-haematological and haematological treatment related adverse events
Cohort, n | ||||||
|---|---|---|---|---|---|---|
Event or grade | 1A | 1B | 2 | 3 | 4 | Total (%) |
Non-haematological | ||||||
Nausea | ||||||
1–2 | 2 | 3 | 1 | 3 | 4 | 13 (57) |
3 | 0 | 0 | 0 | 0 | 0 | 0 |
Fatigue | ||||||
1–2 | 1 | 4 | 1 | 2 | 3 | 11 (48) |
3 | 0 | 0 | 0 | 1 | 0 | 1 (4) |
Vomiting | ||||||
1–2 | 1 | 1 | 0 | 3 | 3 | 8 (35) |
3 | 0 | 0 | 1 | 0 | 0 | 1 (4) |
Peripheral sensory neuropathy | ||||||
1–2 | 0 | 3 | 0 | 1 | 2 | 6 (26) |
3 | 0 | 0 | 1 | 1 | 0 | 2 (9) |
Alopecia | ||||||
1–2 | 0 | 3 | 1 | 2 | 2 | 8 (35) |
3 | 0 | 0 | 0 | 0 | 0 | 0 |
Flushing | ||||||
1–2 | 2 | 3 | 0 | 2 | 1 | 8 (35) |
3 | 0 | 0 | 0 | 0 | 0 | 0 |
Myalgia | ||||||
1–2 | 0 | 3 | 1 | 1 | 2 | 7 (30) |
3 | 0 | 0 | 1 | 0 | 0 | 1 (4) |
Arthralgia | ||||||
1–2 | 0 | 3 | 1 | 1 | 1 | 6 (26) |
3 | 0 | 0 | 0 | 0 | 0 | 0 |
Haematological | ||||||
Anaemia | ||||||
1–2 | 5 | 4 | 2 | 3 | 3 | 17 (96) |
3 | 0 | 0 | 0 | 0 | 1 | 1 (13) |
Leucopenia | ||||||
1–2 | 2 | 4 | 1 | 3 | 2 | 12 (61) |
3 | 0 | 0 | 0 | 3 | 2 | 5 (22) |
Neutropenia | ||||||
1–2 | 2 | 1 | 2 | 0 | 6 | 11 (65) |
3 | 1 | 0 | 0 | 2 | 0 | 3 (13) |
4 | 0 | 0 | 0 | 1 | 2 | 3 (13) |
Thrombocytopenia | ||||||
1–2 | 1 | 2 | 1 | 1 | 1 | 6 (48) |
3 | 1 | 0 | 0 | 1 | 1 | 3 (13) |
