Table 4 Pharmacokinetics of docetaxel according to ABCB1 polymorphisms for postmenopausal patients

From: Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients

Postmenopausal patients ( n =33)

 

AUC ( μ g h l–1)

Clearance (l h–1)

Genotype ( n)

Mean (s.e.)

P *

Mean (s.e.)

P *

T-129C

 TT (26)

4635 (351)

0.8

41.5 (3.4)

0.5

 TC (7)

4462 (565)

 

45.7 (5.9)

 

 CC (0)

    

A61G

 AA (31)

4588 (317)

0.4

43.0 (3.1)

0.4

 AG (2)

4765 (15)

 

33.6 (0.1)

 

 GG (0)

    

C1236T

 CC (14)

4733 (511)

 

42.2 (4.4)

 

 CT (14)

4675 (461)

0.9

41.8 (4.7)

0.9

 TT (5)

4006 (517)

 

44.8 (8.7)

 

G2677T/A

 GG (17)

4612 (425)

 

42.0 (3.6)

 

 GT (12)

4228 (414)

0.4

46.2 (5.9)

0.4

 TT (3)

4553 (476)

 

36.9 (5.0)

 

 TA (1)

8943

 

20.1

 

 GG (17)

4612 (425)

0.8

42.0 (3.6)

0.8

 GT and TT and TA (16)

4584 (431)

 

42.8 (4.8)

 

C3435T

 CC (13)

5075 (481)

 

36.7 (2.8)

 

 CT (14)

4279 (492)

0.2

46.9 (4.9)

0.3

 TT (6)

4309 (539)

 

44.3 (9.4)

 

 CC (13)

5075 (481)

0.1

36.7 (2.8)

0.2

 CT and TT (20)

4288 (373)

 

46.1 (4.3)

 

2677–3435

 GG-CC (12)

5141 (517)

0.1

36.4 (3.0)

0.2

 Others (21)

4288 (356)

 

45.8 (4.1)

 

61–1236–2677–3435

 AA-CC-GG-CC (9)

5507 (645)

0.04

34.7 (3.9)

0.09

 Others (24)

4257 (311)

 

45.3 (3.6)

 

61–1236–2677–3435

 AA-CT-GT-CT (6)

4649 (593)

0.8

41.0 (5.8)

0.9

 Others (27)

4587 (344)

 

42.7 (3.4)

 

1236–2677–3435

 CT-GT-CT (6)

4649 (593)

0.8

41.0 (5.8)

0.9

 Others (27)

4587 (344)

 

42.7 (3.4)

 

1236–2677–3435

 TT-TT-TT (3)

4553 (476)

0.7

36.9 (5.0)

0.6

 Others (30)

4603 (326)

 

43.0 (3.2)

 
  1. Abbreviations: AUC=plasma concentration-time curve; s.e.=standard error.
  2. *Comparisons between groups used the Mann–Whitney test for two groups and the Kruskal–Wallis test for three or more groups. Statistical significance was defined as P<0.005.
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