Table 3 Toxicity experienced by ⩾2 patients thought to be at least possibly related to the study drug
SOC | Preferred term | Grade 1/2 (%) | Grade 3 (%) |
|---|---|---|---|
Gastrointestinal disorders | Constipation | 4 (21) | 0 (0) |
Diarrhoea | 4 (21) | 1 (5) | |
Nausea | 5 (26) | 0 (0) | |
Retching | 2 (10) | 0 (0) | |
Vomiting | 4 (21) | 0 (0) | |
General disorders | Fatigue | 8 (42) | 1 (5) |
Metabolism and nutrition | Decreased appetite | 5 (26) | 0 (0) |
Musculoskeletal and connective tissue disorders | Arthralgia | 2 (10) | 0 (0) |
Muscle spasms | 8 (42) | 1 (5) | |
Myalgia | 3 (16) | 0 (0) | |
Nervous system | Dizziness | 4 (21) | 0 (0) |
Headache | 3 (16) | 0 (0) | |
Hypoaesthesia | 2 (10) | 0 (0) | |
Lethargy | 5 (26) | 0 (0) | |
Skin | Alopecia | 8 (42) | 0 (0) |
Nail disorders | 5 (26) | 1 (5) | |
Pain of skin | 2 (10) | 0 (0) |
